Pregnenolone

Pregnenolone is a pro-hormone that is synthesized in the brain and adrenals, but also in the liver, skin, brain, testicles, ovaries and retina. As a biochemical precursor to DHEA and progesterone, pregnenolone helps to keep a normal balance between these hormones in the body and as a result, helps to modulate the cortisol-driven stress response system, support nerve cell growth and modulate mood. Specifically, when a high-stress lifestyle pushes the stress response system into overdrive, the rise in cortisol can ultimately cause the depletion of pregnenolone and a reduced availability of DHEA and progesterone.